Biochemistry – Kinetics

If an individual ingested 100 mL of methanol, how much 100 proof whiskey (50% ethanol by volume) must be imbibed to reduce the activity of LADH toward methanol to5% of its original value?

Assume the following: the adult human body contains about 40 L of aqueous fluids throughout which ingested alcohols are rapidly and uniformly mixed. The densitiesof ethanol and methanol are 0.79 g/cm. The Km values of LADH are 1.0 x 10-3 for ethanol and 1.0 x 10-2 and KI = Km forethanol.

(In the body, ethanol is oxidized to acetaldehyde by liver alcohol dehydrogenase (LADH). Other alcohols are also oxidized by LADH. Methanol is toxis because it isoxidized to for formaldehyde. Administering ethanol can reduce the toxic effects of methanol ingestion, as ethanol acts as a competitive inhibitor displacingmethanol from active site of LADH.)


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